Mission

Mission statement:


Architecture of the mind

Our mission is to understand how networks of neurons enable the cognitive functions of the brain, including consciousness, perception, movement, learning and social interaction, in health and disease.

The research program integrates three levels of biological complexity:
  • genetic and molecular approaches
  • cellular approaches and network function
  • system and behavioral approaches

The research program is carried out in 17 research groups. In addition, the Institute includes the Netherlands Brain Bank and participates in the Spinoza Centre for Neuroimaging

Scientific Director Pieter R. Roelfsema, PhD
Vice Director Chris I. de Zeeuw, PhD
Managing Director Ronald van der Neut, PhD

 

 

 

Recent Publications

Wassing, R., Benjamins, J.S., Dekker, K., Moens, S., Spiegelhalder, K., Feige, B., Riemann, D., Van der Sluis, S., Van der Werf, Y.D., Talamini, L.M., Walker, M.P., Schalkwijk, F., and Van Someren, E.J.W. Slow dissolving of emotional distress contributes to hyperarousal. PNAS, in press. [abstract]

   

Vermunt, M.W., Tan, S.C., Castelijns, B., Geeven, G., Reinink, P., De Bruijn, E., Kondova, I., Persengiev, S., Netherlands Brain Bank, Bontrop, R., Cuppen, E., De Laat, W., and Creyghton, M.P. Epigenomic annotation of gene regulatory alterations during evolution of the primate brain. Nature Neuroscience, in press. [abstract]

       

Zhu, Q.B., Unmehopa, U., Bossers, K., Hu, Y.T., Verwer, R., Balesar, R., Zhao, J., Bao, A.M., and Swaab, D.F. MicroRNA-132 and early growth response-1 in nucleus basalis of Meynert during the course of Alzheimer's disease. Brain, in press. [abstract]

   

Ten Brinke, M.M., Boele, H.J., Spanke, J.K., Potters, J.W., Komysheva, K., Wulff, P., IJpelaar, A.C.H.G., Koekkoek, S.K.E., and De Zeeuw, C.I. Evolving models of Pavlovian conditioning: cerebellar cortical dynamics in awake behaving mice. Cell Reports 13 (2015) 1977-1988. [abstract]

  

Zhou, L., Yang, D., Wang, D.J., Xie, Y.J., Zhou, J.H., Zhou, L., Huang, H., Han, S., Shao, C.Y., Li, H.S., Zhu, J.J., Qiu, M.S., De Zeeuw, C.I., and Shen, Y. Numb deficiency in cerebellar Purkinje cells impairs synaptic expression of metabotropic glutamate receptor and motor coordination. PNAS, in press. [abstract]

  

Kros, L., Eelkman Rooda, O.H., De Zeeuw, C.I., and Hoebeek, F.E. Controlling cerebellar output to treat refractory epilepsy. Trends in Neurosciences, in press. [abstract]

    

Zhu, Q.B., Unmehopa, U., Bossers, K., Hu, Y.T., Verwer, R., Balesar, R., Zhao, J., Bao, A.M., and Swaab, D.F. MicroRNA-132 and Early growth response-1 in nucleus basalis of Meynert during the course of Alzheimer's disease. Brain, in press.

    

Schreiber, J., Vegh, M.J., Dawitz, J., Kroon, T., Loos, M., Labonte, D., Li, K.W., Van Nierop, P., Van Diepen, M.T., De Zeeuw, C.I., Kneussel, M., Meredith, R.M., Smit, A.B., and Van Kesteren, R.E. Ubiquitin ligase TRIM3 controls hippocampal plasticity and learning by regulating synaptic y-actin levels. Journal of Cell Biology, in press. [abstract]

     

Bruinsma, C.F., Schonewille, M., Gao, Z., Aronica, E.M.A., Judson, M.C., Philpot, B.D., Hoebeek, F.E., Van Woerden, G.M., De Zeeuw, C.I., and Elgersma, Y. Dissociation of locomotor and cerebellar deficits in a murine Angelman syndrome model. Journal of Clinical Investigation, in press. [abstract]

          

Huang, Y., Skwarek-Maruszewska, A., Horre, K., Vandewyer, E., Wolfs, L., Snellinx, A., Saito, T., Radaelli, E., Corthout, N., Colombelli, J., Lo, A.C., Van Aerschot, L., Callaerts-Vegh, Z., Trabzuni, D., Bossers, K., Verhaagen, J., Ryten, M., Munck, S., D'Hooge, R., Swaab, D.F., Hardy, J., Saido, T.C., De Strooper, B., and Thathiah, A. Loss of GPR3 reduces the amyloid plaque burden and improves memory in Alzheimer's disease mouse models. Science Translational Medicine 7 (2015) 309ra164. [abstract]

                          

Reddy, L., Poncet, M., Self, M.W., Peters, J.C., Douw, L., Van Dellen, E., Claus, S., Reijneveld, J.C., Baayen, J.C., and Roelfsema, P.R. Learning of anticipatory responses in single neurons of the human medial temporal lobe. Nature Communications 6 (2015) 8556. [abstract]

  

Fagoe, N.D., Attwell, C.L., Kouwenhoven, D., Verhaagen, J., and Mason, M.R. Over-expression of ATF3 or the combination of ATF3, c-Jun, STAT3 and Smad1 promotes regeneration of the central axon branch of sensory neurons but without synergistic effects. Human Molecular Genetics, in press. [abstract]

    

Jeurissen, D., Van Ham, A.F., and Self, M.W. The neural representation of multiple objects in the primate visual system. Journal of Neuroscience 35 (2015) 12612-4. [abstract]

More publications 

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News

8 February 2016
Press release: Volunteers achieve breakthrough insight insomnia, trauma and depression. Read more [Dutch]
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4 December 2015
The NIN PhD Brain Award of this year is won by Mehran Ahmadlou.
See his article in Nature Communications
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27 November 2015, TEDxAmsterdam
Damiaan Denys [view]
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26 November 2015
Former NIN-OIO Henrique Alves is awarded the Donders price 2016 for the best thesis in Ophthalmology that appeared in 2014. Supervisor Joost Verhaagen, co-supervisor Jan Wijnholds.



July 2015

Jasper Poort received a VENI grant for the project: Visual perception during navigation.


20 May 2015

Eus van Someren received an ERC Advanced Grant. Read more


27 March 2015

HRH King Willem-Alexander paid a working visit to the Netherlands Institute for Neuroscience [news]


NINnews May 2015

NINnews December 2013

NINnews June 2013

NINnews May 2012

NINnews October 2011

NINnews April 2011

NINnews November 2010

NINnews June 2010

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Events

Dick Swaab: breinvriendelijk theatercollege

23 Februari 2016, 20:15 h, Den Haag
7 March 2016, 20:00 h, Den Bosch
www.theatercolleges.nl
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10 February 2016, 15:45 h, Aula VU Amsterdam
    
Johan Winnubst will defend his thesis entitled: Activity-dependent clustering of co-active synapses during development.
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24 February 2016, 20:00 h, Maastricht

Lezing door Dick Swaab:

Ons culturele brein
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10 March 2016, 13:45 h, Aula VU Amsterdam

Danique Jeurissen will defend her thesis entitled: Perceptual grouping of complex objects in the primate visual system.
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11 March 2016, de Philharmonie Haarlem
           

Congres 'Bestaat de vrije wil?'
           

Met Daniel Dennett, Dick Swaab en Victor Lamme [info]


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