Mission statement:

Architecture of the mind

Our mission is to understand how networks of neurons enable the cognitive functions of the brain, including consciousness, perception, movement, learning and social interaction, in health and disease.

The research program integrates three levels of biological complexity:
  • genetic and molecular approaches
  • cellular approaches and network function
  • system and behavioral approaches

The research program is carried out in 17 research groups. In addition, the Institute includes the Netherlands Brain Bank and participates in the Spinoza Centre for Neuroimaging

Scientific Director Pieter R. Roelfsema, PhD
Vice Director Chris I. de Zeeuw, PhD
Managing Director Ronald van der Neut, PhD




Recent Publications

Kros, L., Eelkman Rooda, O.H., De Zeeuw, C.I., and Hoebeek, F.E. Controlling cerebellar output to treat refractory epilepsy. Trends in Neurosciences, in press. [abstract]


Zhu, Q.B., Unmehopa, U., Bossers, K., Hu, Y.T., Verwer, R., Balesar, R., Zhao, J., Bao, A.M., and Swaab, D.F. MicroRNA-132 and Early growth response-1 in nucleus basalis of Meynert during the course of Alzheimer's disease. Brain, in press.


Schreiber, J., Vegh, M.J., Dawitz, J., Kroon, T., Loos, M., Labonte, D., Li, K.W., Van Nierop, P., Van Diepen, M.T., De Zeeuw, C.I., Kneussel, M., Meredith, R.M., Smit, A.B., and Van Kesteren, R.E. Ubiquitin ligase TRIM3 controls hippocampal plasticity and learning by regulating synaptic y-actin levels. Journal of Cell Biology, in press. [abstract]


Bruinsma, C.F., Schonewille, M., Gao, Z., Aronica, E.M.A., Judson, M.C., Philpot, B.D., Hoebeek, F.E., Van Woerden, G.M., De Zeeuw, C.I., and Elgersma, Y. Dissociation of locomotor and cerebellar deficits in a murine Angelman syndrome model. Journal of Clinical Investigation, in press. [abstract]


Huang, Y., Skwarek-Maruszewska, A., Horre, K., Vandewyer, E., Wolfs, L., Snellinx, A., Saito, T., Radaelli, E., Corthout, N., Colombelli, J., Lo, A.C., Van Aerschot, L., Callaerts-Vegh, Z., Trabzuni, D., Bossers, K., Verhaagen, J., Ryten, M., Munck, S., D'Hooge, R., Swaab, D.F., Hardy, J., Saido, T.C., De Strooper, B., and Thathiah, A. Loss of GPR3 reduces the amyloid plaque burden and improves memory in Alzheimer's disease mouse models. Science Translational Medicine 7 (2015) 309ra164. [abstract]


Reddy, L., Poncet, M., Self, M.W., Peters, J.C., Douw, L., Van Dellen, E., Claus, S., Reijneveld, J.C., Baayen, J.C., and Roelfsema, P.R. Learning of anticipatory responses in single neurons of the human medial temporal lobe. Nature Communications 6 (2015) 8556. [abstract]


Fagoe, N.D., Attwell, C.L., Kouwenhoven, D., Verhaagen, J., and Mason, M.R. Over-expression of ATF3 or the combination of ATF3, c-Jun, STAT3 and Smad1 promotes regeneration of the central axon branch of sensory neurons but without synergistic effects. Human Molecular Genetics, in press. [abstract]


Jeurissen, D., Van Ham, A.F., and Self, M.W. The neural representation of multiple objects in the primate visual system. Journal of Neuroscience 35 (2015) 12612-4. [abstract]


Lorteije, J.A., Zylberberg, A., Ouellette, B.G., De Zeeuw, C.I., Sigman, M., and Roelfsema, P.R. The formation of hierarchical decisions in the visual cortex. Neuron, in press. [abstract]


Winnubst, J., Cheyne, J.E., Niculescu, D., and Lohmann, C. Spontaneous activity drives local synaptic plasticity in vivo. Neuron 87 (2015) 399-410. [abstract]     

More publications 



26 November 2015
Former NIN-OIO Henrique Alves is awarded the Donders price 2016 for the best thesis in Ophthalmology that appeared in 2014. Supervisor Joost Verhaagen, co-supervisor Jan Wijnholds.

11 November 2015

Help us win Researcher Joost Verhaagen is in the race to win €50,000 with the Medical Inspiration Prize 2015 and you can help us win!

17 July 2015

Jasper Poort received a VENI grant for the project: Visual perception during navigation.

20 May 2015

Eus van Someren received an ERC Advanced Grant. Read more

27 March 2015

HRH King Willem-Alexander paid a working visit to the Netherlands Institute for Neuroscience [news]

NINnews May 2015

NINnews December 2013

NINnews June 2013

NINnews May 2012

NINnews October 2011

NINnews April 2011

NINnews November 2010

NINnews June 2010




3 December 2015, 13:45 h, Aula VU


Timo van Kerkoerle will defend his thesis entitled: Feedforward and feedback processing in monkey visual cortex.


Supervisor: Pieter Roelfsema, co-supervisor: Matt Self

Dick Swaab: breinvriendelijk theatercollege
14 December, 20:00 h, Rotterdam
12 Januari 2016, 20:00 h, Leeuwarden
18 Januari 2016, 20:00 h, Heerlen
11 March 2016, de Philharmonie Haarlem

Congres 'Bestaat de vrije wil?'

Met Daniel Dennett, Dick Swaab en Victor Lamme